国际麻醉学与复苏杂志   2015, Issue (6): 7-7
    
α-氨基-3羟基-5-甲基-4-异恶唑丙酸受体在瑞芬太尼痛觉过敏中作用的研究进展
王志芬, 元元, 王国林1()
1.天津医科大学总医院 麻醉研究所
Research advances of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptor in remifentanil induced hyperalgesia
 全文:
摘要：

背景　α-氨基-3羟基-5-甲基-4-异恶唑丙酸（α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate， AMPA）受体是一种兴奋性递质谷氨酸离子通道型受体，谷氨酸可以与之结合并介导突触后膜电流，引起神经元兴奋性增强，从而导致痛觉信息上传增加，进而引起痛觉敏感化。　目的　探讨 AMPA受体在瑞芬太尼痛觉过敏发生及维持中的作用。　内容　对AMPA受体的基本特征、运输、功能及其在瑞芬太尼痛觉过敏中的研究进行综述。　趋向　通过 AMPA受体在瑞芬太尼痛觉过敏中的研究，为瑞芬太尼痛觉过敏的预防及治疗提供新靶点。
关键词： α-氨基-3羟基-5-甲基-4-异恶唑丙酸受体；　痛觉过敏；　瑞芬太
Abstract:

Background　α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate（AMPA） receptor is one of the excitatory ionotropic glutamate receptors， the excitatory ionotropic glutamate receptors. Glutamate can bind to AMPA receptor and mediate postsynaptic currents， which enhances neuronal excitability and pain information upload， and finally causes hyperalgesia.　Objective　This review focuses on the role of AMPA receptor in remifentanil induced hyperalgesia．　Content　This review provided a comprehensive summary of the basic features， trafficking and function of AMPA receptor， as well as its roles in remifentanil induced hyperalgesia．　Trend　Targeting AMPA receptor may provide a new approach for the treatment of remifentanil induced hyperalgesia．
Key words: α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptor；　Hyperalgesia；　Remifentanil