Background Local anesthetic commonly used in clinical has short biological half-life in vivo, and the high local drug concentration in tissue can easily produce central nervous system and cardiovascular toxicity. Objective To review the research progress of local anesthetic PLGA sustained release drug delivery systems. Content This paper reviews the researches in four areas, such as the research on PLGA, the type and preparation process of local anesthetic PLGA microparticles, the results in different experimental animal models and the progress of clinical research and the presence of defects and improvement.Trend Researches on local anesthetic delivery system can provide better clinical analgesic and anesthetic, but some qualities of the microparticles should be improved, such as the drug loading and the production process .