Ｏｂｊｅｃｔｉｖｅ　To observe the effect and safety of total stage of labor analgesia.　Methods　Ninty full-term single birth primiparous women were randomized to three groups（n=30）: the total stage analgesia group（group A），active-phase analgesia group（group B） and control group（group C）. Patients in groups A and B were administrated combined spinal epidural anesthesia （CSEA）， then epidural tube connected with electronic analgesia pump for labor analgesia. CSEA analgesia was performed while just getting into birth process， and maintained to 2 h after delivery in group A. CSEA analgesia was given at cervix dilation≥3 cm and maintained to cervis dilation in group B. No analgesia was given in group C. The visual analogue scales（VAS） score， lower limbs motor block， labor time and method， adverse reaction of parturients during birth process， postpartum hemorrhage 24 h after labor， neonatal Apgar score were recorded. The venous blood samples of women were collected at the beginning of labor， active phase full dilatation and infant birth for mensuration of plasma renin activity（PRA）， angiotensin Ⅱ（AⅡ）， aldosterone（ALD） and cortisol （COR）.　Results　There were no significant differences among the three groups total stage of labor analgesia， the conversion rate to caesarean section， lower limbs motor block， postpartum bleeding and newborn's Apgar score（P>0.05）. The VAS score for the first stage of the incubation period was （1.5±0.8）, the first active phase was （0.7±0.7）, the second stage of labor was （1.2±1.3）, and the third stage of labor was （2.4±1.9） which in group A were significantly differences than that in group C（P<0.01）. During the stage of active phase full dilatationg， PRA was （3.5±1.9） μg/L, ALD was （239±74） μg/L, COR was （575±166） nmol/L and for infant brith PRA was （3.5±1.5） μg/L, ALD was （200±68） μg/L, COR was （512±146） nmol/L， which in group A obviously reduced compared with those in contemporaneous groups B and C （P<0.05）.　Conclusions　Labor analgesia with CSEA during total delivery course can effectively alleviate labor pain and relieve stress， and have little effect on labor time and method， suggesting it is worthy of wide promotion of safe and effective labor analgesia way.