国际麻醉学与复苏杂志   2015, Issue (8): 0-0
    
穴位电刺激对颈椎手术患者全身麻醉诱导和苏醒期应激激素水平的影响
张维亮, 刘新, 苏帆1()
1.山东中医药大学附属医院
Effects of acupoint electric stimulation on the stress hormone levels during induction and recovery period of general anesthesia in patients with cervical operation
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摘要:

目的 探讨穴位电刺激对颈椎手术患者全身麻醉诱导和苏醒期应激激素水平的影响。 方法 美国麻醉医师协会(ASA)分级Ⅱ~Ⅲ级颈椎手术患者60例,按随机数字表法分为两组:治疗组(T组)和对照组(C组),每组30例。T组在插管前30 min采用长城牌KWD?蛳808Ⅰ型全能脉冲电疗仪刺激合谷和内关穴,持续20 min,开始实施静脉麻醉诱导。术中持续刺激双侧合谷和内关穴,在手术结束前30 min停止。C组行常规麻醉,合谷、内关穴贴电极片而不进行电刺激。两组均采用相同的麻醉方法。分别于入室稳定10 min后(T0)、气管插管即刻(T1)、插管后3 min(T2)、拔管即刻(T3)、拔管后3 min(T4)时刻抽取动脉血,测定皮质醇(cortisol, COR)及血糖(glucose, GLU)水平。 结果 两组患者年龄、体重、手术时间、出血量差异无统计学意义(P>0.05)。组内比较两组患者COR及GLU水平在T1 [(293±80) μg/L、(6.1±1.8) mmol/L,(276±82) μg/L、(5.2±1.0) mmol/L],T2[(298±83) μg/L、(6.3±2.1) mmol/L,(277±84) μg/L、(5.4±0.9) mmol/L)],T3[(253±90) μg/L、(5.8±1.7) mmol/L,(239±89) μg/L、(5.6±1.5) mmol/L],T4 [(275±79) μg/L、(6.2±1.8) mmol/L,(263±80) μg/L、(5.7±1.4) mmol/L]时刻高于T0 [(211±54) μg/L、(4.9±0.8) mmol/L,(206±56) μg/L、(4.7±0.7) mmol/L](P<0.05)。组间比较,C组患者COR及GLU水平在T1 [(293±80) μg/L,(6.1±1.8) mmol/L],T2 [(298±83) μg/L,(6.3±2.1) mmol/L],T3 [(253±90) μg/L,(5.8±1.7) mmol/L],T4 [(275±79) μg/L,(6.2±1.8) mmol/L]时刻均高于同时刻T组(P<0.05)。 结论 穴位电刺激应用于颈椎手术患者可明显减轻全身麻醉诱导和苏醒期应激反应,具有一定的临床应用价值。

关键词: 穴位电刺激; 颈椎手术; 应激反应
Abstract:

Objective To investigate the effects of acupoint electric stimulation on the stress hormone levels during induction and recovery period of general anesthesia in patients with cervical operation. Methods Sixty ASA classⅡ-Ⅲpatients with cervical operation were randomly divided into the treatment group (group T) and the control group (group C) according to the method of random digits table. Bilateral Hegu and Neiguan Great were stimulated continuously 20 min by the Wall KWD-808 type Ⅰ universal pulse electrotherapy instrument before intubation 30 min, and stopped before the end of the operation 30 min in group T. Routine anesthesia without any treatment except for Hegu, Neiguan point electrodes pasting underwent in group. Both groups adopted the same anesthesia. Arterial blood samples were collected respectively at the time of 10 min after delivering into operation room (T0), tracheal intubation (T1), 3 min after intubation (T2), immediately after extubation (T3), 3 min after extubation (T4). Blood samples were centrifuged for 10 min to detect the level of cortisol(COR) and glucose(GLU) in serum. Results There was no significant difference (P>0.05) between two groups in age, weight, operation time, bleeding volume of patients. The COR and the GLU level of T1[(293±80) μg/L,(6.1±1.8) mmol/L,(276±82) μg/L,(5.2±1.0) mmol/L],T2[(298±83) μg/L,(6.3±2.1) mmol/L,(277±84) μg/L,(5.4±0.9) mmol/L],T3[(253±90) μg/L,(5.8±1.7) mmol/L,(239±89) μg/L,(5.6±1.5) mmol/L],T4[(275±79) μg/L,(6.2±1.8) mmol/L,(263±80) μg/L,(5.7±1.4) mmol/L]were always higher than T0[(211±54) μg/L,(4.9±0.8) mmol/L,(206±56)μg/L,(4.7±0.7) mmol/L](P<0.05) within groups. The COR and GLU levels of patients in T1[(293±80) μg/L,(6.1±1.8) mmol/L],T2 [(298±83) μg/L,(6.3±2.1) mmol/L],T3[(253±90) μg/L,(5.8±1.7) mmol/L],T4[(275±79) μg/L,(6.2±1.8) mmol/L] in group C were higher than the same time in group T(P<0.05). Conclusions Acupoint electric stimulation applied to patients with cervical operation, can significantly reduce the stress effect during induction and recovery of anesthesia, and has a significance in clinical application.

Key words: Acupoint electric stimulation; Cervical operation; Stress response