Ｏｂｊｅｃｔｉｖｅ　To compare the effects of remifentanil-propofol and sufentanil-propofol target-controlled intravenous anesthesia in brain surgery, and their respective influences on hemodynamics and plasma hormone levels.　Methods　According to the random number table, One hundred and eight patients elective for brain surgery were randomly divided into remifentanil group(remifentanil-propofol) and sufentanil group(sufentanil-propofol), n=54. The hemodynamic changes of two groups were compared at the following five time points: before induction(T0), intubation(T1), 1 min after intubation(T2), 5 min after intubation(T3), extubation(T4). The plasma hormone levels at each point, including serum norepinephrine (NE), plasma angiotensin Ⅱ(AngⅡ), plasma renin activity(PRA)and aldosterone(ALD) were detected by radioimmunoassay. We observed anesthesia recovery and adverse reactions at the same time.　Results　Compared with T0 , SBP, DBP, HR, SpO2 and other indicators of two groups during T1-T4 were all significantly decreased(P<0.01)， and the data of sufentanil group higher than those remfentanil group(P<0.01). Compared with T0, during T1-T4, NE, AngII, PRA and ALD in remifentanil group significantly increased(P<0.01). Compared with T0, during T2-T4, NE and ALD in sufentanil group significantly increased(P<0.05), while AngⅡ and PRA slightly increased, and the latter difference was not statistically significance (P>0.05). During T2-T4, NE levels in two groups were significantly different(P<0.01), during T1-T4, AngⅡ and PRA levels in two groups were significantly different(P<0.01), during T3-T4, ALD levels in two groups were significantly different(P<0.05). In remifentanil group, spontaneous breathing recovery time［(6.2±1.6) min］, opening eyes time［(7.1±1.8) min］, conscious time［(13.7±2.4) min］ and extubation time［(6.3±0.8) min］ were significantly shorter than sufentanil group(P<0.05). No serious complications occurred in both groups.　Conclusions　Compared with remifentanil, sufentanil can reduce cardiovascular stress response in patients undergoing brain surgery and obtained better hemodynamic indicators. But remifentanil can get a good induction effect with quick recovery, self-breathing, and a short time of extubation.