国际麻醉学与复苏杂志   2015, Issue (8): 0-0
    
内质网应激在心肌缺血预处理中的作用
陈满丽, 陈立建, 顾尔伟1()
1.安徽医科大学第一附属医院麻醉科
The roles of endoplasmic reticulum stress in cardioprotection induced by ischemia preconditioning
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摘要：

背景　内质网应激（endoplasmic reticulum stress， ERS）是细胞内对抗氧化应激、钙超载、能量耗竭的一种适应性反应，适度的ERS通过促生存途径保护细胞。心肌缺血/再灌注（ischemia/reperfusion， I/R）期间诱导过度的ERS发生，导致心肌损伤。心肌缺血预处理（ischemia preconditioning， IPC）可通过调节ERS发挥心肌保护作用。　目的　综述ERS调节心肌IPC的作用及其影响因素。　内容　系统阐述ERS在调节细胞生存与凋亡、心肌I/R过程中的作用及IPC调节ERS的机制。　趋向　心肌IPC通过调节ERS反应来发挥心肌保护效应受多方面因素影响，其具体机制仍有待进一步研究。
关键词： 内质网应激；　缺血/再灌注；　缺血预处理；　心肌保护
Abstract:

Background　Endoplasmic reticulum stress（ERS） is a type of cellular adaptive reaction against oxidative stress， calcium overload and ATP depletion. Mild ERS protects myocardium via pro-survival pathways. Myocardium ischemia/reperfusion（I/R） would induce prolonged ERS， which may result in irreversible injury. ERS is involved in the cardioprotection induced by ischemia preconditioning（IPC）.　Objective　This review focused on the factors which regulate ERS mediated by IPC and demonstrated its possible mechanisms.　Content　To discuss the roles of ERS in cells survival， apotosis and cardioprotection induced by IPC.　Trend　There are many factors involved in the cardioprotection induced by IPC via regulating ERS， and its mechanisms need further studies.
Key words: Endoplasmic reticulum stress；　Ischemia/reperfusion；　Ischemia preconditioning；　Cardioprotection