Excitatory amino acid transporter 2(EAAT2): A new target for the treatment of ischemic brain injury ？ Zhi Lijun, Xu Pengcheng, Yan Xuejun. Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical College, Jiangsu Province Key Laboratory of Anesthesiology and Analgesia Application Technology, Xuzhou 221004, China Corresponding author: Yan Xuejun, Email:yanxuejun1967@163.com [Abstract] Background The mechanism, prevention and treatment of ischemic brain injury has been concern for people, but still no breakthrough. Objective To provide the new idea for the research of ischemic brain damages, we select glutamate transporter EAAT2 as the point of entry. Content This article reviewed the mechanism of glutamate transport through EAAT2, the role of EAAT2 in the development of ischemic brain injury and the research progress of EAAT2 modulators in attenuating ischemic brain injury. Trend Glutamate transporter EAAT2 may be a promising target for the therapy of ischemic brain injury.