国际麻醉学与复苏杂志   2016, Issue (2): 2-2
    
肢体缺血预处理减轻肝缺血/再灌注损伤的研究进展
李艳超, 潘道波1()
1.江苏省麻醉学重点实验室 江苏省麻醉与镇痛应用技术重点实验室
The research progress of limb ischemia preconditioning in reducing hepatic ischemia/reperfusion injury
 全文:
摘要：

背景　肝缺血/再灌注损伤（hepatic ischemia/reperfusion injury， HI/RI）是肝外科手术及肝移植中常见的病理生理现象，是术后肝功能衰竭和移植物无功能的主要原因。研究表明肢体缺血预处理（limb ischemia preconditioning， LIPC）可减轻HI/RI，具体机制仍不清楚。　目的　通过综述LIPC减轻HI/RI的可能机制，为临床减轻HI/RI提供新的思路。　内容　介绍HI/RI机制及LIPC减轻HI/RI的可能作用机制。　趋向　LIPC作为减轻HI/RI的措施具有重大的临床应用价值。
关键词： 肢体缺血预处理；　缺血/再灌注损伤；　肝损伤
Abstract:

Background　Hepatic ischemia/reperfusion injury(HI/RI) is common pathophysiological phenomenon in liver surgery and liver transplantation. HI/RI is the most important factor of liver dysfunction and non-function of graft after hepatic surgery.Although it has been indicated that limb ischemia preconditioning(LIPC) can reduce HI/RI, its mechanism is not completely elucidated.　Objective　This review summarizes the potential mechanism of LIPC reducing HI/RI, which provides new ideas of preventing HI/RI in clinic.　Content　This review describes the potential mechanism of HI/RI and LIPC reducing HI/RI.　Trend　LIPC as a way of preventing HI/RI has significant clinical value.
Key words: Limb ischemia preconditioning;　Ischemia/reperfusion injury;　Hepatic injury