背景 早期生长反应基因-1（the early growth response gene-1， Egr-1）参与长时程增强、促进神经元发生过程，其蛋白表达与突触可塑性及长期记忆的巩固、再巩固和消除密切相关。 目的 以Egr-1基因的表达变化为切入点，为术后认知功能障碍的发生机制及防治手段提供更多研究靶点。 内容 全面阐述Egr-1的结构特点、分布、表达及其对学习记忆不同阶段的影响。 趋向 Egr-1基因在学习记忆的不同阶段发挥不同作用，但具体的分子信号通路及其在术后认知功能障碍中的作用尚有待进一步研究。
Background The early growth response gene-1(Egr-1) is considered to be a triggering mechanism that maintains long term potentiation and activates neurogenesis. The expression of Egr-1 protein is closely associated with the consolidation, reconsolidation and extinction of long term memory. Objective Providing potential research targets for studying the mechanism and treatment of postoperative cognitive dysfunction. Content We review the structure, expression pattern of Egr-1 protein and its roles in learning and memory. Trend Egr-1 plays different roles in different phases of memory, but the specific signaling pathways and their relationship with postoperative cognitive dysfunction deserve further clarification.
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