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摘要：
目的：通过对随机对照实验的数据进行Meta分析，系统评价氯诺昔康超前镇痛对术后镇痛的效果和安全性。方法：检索PubMed、Embase、Cochrane Library、CNKI、万方和知网等文献数据库，查找氯诺昔康超前镇痛对术后镇痛的效果和安全性的随机对照实验，并由两位研究人员对资料进行筛选与评价，使用RevMan5.3软件对结果进行Meta分析。结果：共纳入4个随机对照实验。实验组术前静脉注射氯诺昔康，对照组使用安慰剂。Meta分析结果显示，患者术后VAS评分在各时间点情况分别为：4h（MD=-1.58，95%CI[-2.38,-0.77]，p=0.0001）；8h（MD=-1.43，95%CI[-2.09,-0.77]，p＜0.0001）；12h（MD=-1.35，95%CI[-1.72,-0.98]，p＜0.00001）；24h（MD=-1.02，95%CI[-1.29,-0.76]，p＜0.00001）。不良反应发生情况为（RR=1，95%CI[0.47,2.12]，p=1）。结论：鉴于现有研究结果，氯诺昔康超前镇痛对术后4h、8h、12h、24h患者具有镇痛效果，结果具有统计学意义，氯诺昔康超前镇痛产生不良反应情况尚不明朗。
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Abstract: Objective: Meta analysis from randomized controlled trial data, systematic review the effect and safty of preemptive analgesia with lornoxicam on postoperative analgesia. Methods: We searched PubMed, Embase, Cochrane Library, CNKI, Articles and HowNet and other literature database for lornoxicam preemptive analgesia on postoperative analgesic efficacy and safety of randomized controlled trials by two researchers the data were screened and evaluated. Use RevMan5.3 to Meta-analysis. Results: A total of four randomized controlled trials. Before the experiment group preoperative intravenous lornoxicam, the use of a placebo control group. Meta analysis showed that VAS scores at each time point were the case: 4h (MD = -1.58,95% CI [-2.38, -0.77], p = 0.0001); 8h (MD = -1.43,95% CI [-2.09, -0.77] , p <0.0001); 12h (MD = -1.35,95% CI [-1.72, -0.98], p <0.00001); 24h (MD = -1.02,95% CI [-1.29, -0.76], p <0.00001 ). Adverse reaction case (RR = 1,95% CI [0.47,2.12], p = 1). Conclusion: In view of the existing research results, lornoxicam preemptive analgesia on postoperative 4h, 8h, 12h, 24h have an analgesic effect in patients, the results were statistically significant, preemptive analgesia with lornoxicam adverse reactions is not clear.
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