Ｏｂｊｅｃｔｉｖｅ　To investigate the effects of hydrogen-rich saline on bone cancer pain in rats and lectin-like oxidized low-density lipoprotein receptor-1(LOX-1)/NF-κB pathway in rat spinal cords.　Methods　Thirty two female SD rats, weighing 180－200 g, were randomly assigned into 4 groups (n=8) using a random number table: sham operation group (group S), bone cancer pain group (group BCP), BCP+hydrogen-rich saline group(group BH2), BCP+isotonic saline group(group BS). Group BH2 were intraperitoneally injected hydrogen-rich saline(5 mg/kg), group BS were intraperitoneally injected control-saline(5 mg/kg) on 1, 3, 5, 7, 9, 11, 13 d after the operation. Paw mechanical withdrawal threshold(PMWT) and paw thermal withdrawal latency(PTWL) were measured before operation and on 1, 3, 5, 7, 10, 12, 14 d after the operation. The rats were then sacrificed and L4-L6 segments of the spinal cord were removed for determination of LOX-1, p-NF-κB expression using Western blot on 14 d.　Results　Compared with group S, PWMT and PTWL in group BCP were significantly decreased from 3 d to 14 d(P＜0.05). Compared with group BS, PWMT and PTWL in group BH2 were significantly increased from 7 d to 14 d after operation(P＜0.05). Compared with group S, LOX-1, p-NF-κB were significantly upregulated in group BCP and group BS(P＜0.05). Compared with group BS, LOX-1, p-NF-κB were significantly downregulated in group BH2(P＜0.05).　Conclusions　Intrathecal injection of hydrogen-rich saline significantly relieves bone cancer pain through suppression of LOX-1/NF-κB pathway in rats spinal cords.