Background　The use of physiologically regulated, reproducible animal models is crucial to the study of global cerebral ischemia/reperfusion(I/R) injury--both the mechanisms governing its occurrence and potential therapeutic strategies.　Objective　To summarize the study and application status of rodent global cerebral I/R models.　Content　To discuss the build, influence factor, and evaluation method of rodent global cerebral I/R models.　Trend　With increased application of those models who were closer to clinical by the improvement of experiment technology, there must be more choice for laboratory investigation of cerebral resuscitaton.