背景：蒽环类药物因为其良好的抗肿瘤特性被广泛应用于各类血液系统肿瘤及实体肿瘤，如淋巴瘤，软组织肿瘤，乳腺癌，胃癌，卵巢癌等。但在其应用于临床后不久即被报道出有严重的副作用，包括骨髓抑制以及致命性的心脏毒性。目的：本文旨在探讨丙泊酚为基础的静脉麻醉对接受过蒽环类药物化疗后患者围术期的心血管危险事件及其影响。内容：本文综述了用于乳癌新辅助化疗的蒽环类药的心脏毒性、蒽环类药物治疗后的患者围术期心血管危险事件及心脏保护策略。趋向：临床麻醉中应重视蒽环类药物本身对心肌细胞的影响，合理用药和管理，减少蒽环类药物治疗后的患者围术期心血管危险事件发生。
Background: Anthracyclines are one of the most effective anti-tumors antibiotics and they are widely used in hematologic and solid tumors like lymphoma, soft-tissue tumor, gastric cancer, breast cancer and ovarian cancer. But it were reported to have serious side-effects including cardiotoxicity of myocardium and myelosuppression soon after the first use. Purpose: This review is aim to discuss the effect of propofol based intravenous anesthesia in anthracycline exposed patient in perioperative period. Content: The cardiotoxity after anthracycline neoadjuvant chemotherapy, perioperative cardiaovascular events after anthracycline chemotherapy and its protection strategy. Trend: The cardiotoxity after anthracycline chemotherapy should take into account to reduce the cardiovascular events in clinical anesthesiology.
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