国际麻醉学与复苏杂志   2017, Issue (8): 0-0
    
动力相关蛋白1的小泛素化相关修饰物化修饰在脑缺血/再灌注损伤中的作用
张高峰, 尹曾, 陈怀龙, 李秋杰, 张照亮, 时飞, 王明山1()
1.山东省青岛市市立医院
Post-translational modification of dynamin-related protein 1 by small ubiquitin-related modifier in cerebral ischemia/reperfusion injury
 全文:
摘要：

背景　近年研究发现动力相关蛋白1（dynamin-related protein 1， Drp1）介导的线粒体分裂在脑缺血/再灌注损伤（cerebral ischemia/reperfusion injury， CI/RI）中发挥了重要作用，Drp1的小泛素化相关修饰物（small ubiquitin-related modifier，SUMO）化修饰能影响自身生物学效应。　目的　阐述Drp1的 SUMO化修饰在CI/RI中的作用。　内容　分别描述Drp1蛋白、SUMO蛋白、SUMO相关酶（SUMO化酶/去SUMO化酶）及SUMO化修饰对Drp1生物学效应的影响。　趋向　研究SUMO化修饰影响Drp1的生物学效应的机制，为减轻或治疗CI/RI找到新的靶点或提供新的思路。
关键词： 动力相关蛋白1；　小泛素化相关修饰物；　线粒体分裂；　凋亡；　缺血/再灌注损伤
Abstract:

Background　Mitochondrial fission mediated by dynamin-related protein 1(Drp1) plays an important role in cerebral ischemia/reperfusion injury (CI/RI), and biological effects of Drp1 are altered by small ubiquitin-related modifier(SUMO) through SUMOylation.　Objective　To investigate the effects of Drp1 SUMOylation on CI/RI.　Content　Drp1 belongs to dynamin family, and its upregulation correlates with the fission of mitochondrial, a critical process in apoptosis. SUMOylation and deSUMOylation are a pair of opposite procedures in post-translational modification of Drp1, respectively attenuating and enhancing the binding of Drp1 with mitochondrial. The balance between SUMOylation and deSUMOylation determines the damages following CI/RI.　Trend　Stabilizing or promoting SUMOylation of Drp1 could be a novel strategy to limit the damage of CI/RI.
Key words: Dynamin-related protein 1;　Small ubiquitin-related modifier;　Mitochondrial fission;　Apoptosis;　Ischemia/reperfusion injury