Abstract: Objective To investigate the effects of different analgesia regimens on fast recovery in patients following radical operation for gastric cancer. Methods A total of 67 gastric cancer patients subjected to radical operation were randomly divided into three groups, receiving epidural analgesia (EA group, n=20), intravenous analgesia (PCIA group, n=24) and subcostal transverse abdominis plane block(STAP group, n=23), respectively. The consumption of sevoflurane, sufentanil and vasoactive drugs during operation, VAS score at 1, 6, 12, 24, 48, 72 h after operation, and pethidine consumption after operation were recorded. Recovery of gastrointestinal function, first postoperative feeding time, ambulation time, duration of stay in hospital and the occurrence of adverse effects were compared among three groups. Results Compared with PCIA group(3.8±2.0, 4.7±1.8, 6.5±1.7), EA group and STAP group have less VAS scores in T1 [(2.3±1.2), (3.1±2.3)], T2 [(2.3±1.1), (3.4±2.0)], T3 [(2.8±1.1), (3.6±2.0)] respectively and less occurrence of nausea and vomiting, fatigue and dizziness(P<0.05). Compared with EA group, PCIA group and STAP group have more consumption of sufentanil, pethidine and less consumption of ephedrine and less occurrence of hypotension. Recovery time of gastrointestinal function [(37±12), (50±16), (74±13) h], first postoperative feeding time [(47±10), (61±15), (89±11) h], and ambulation time [(41±15), (54±18), (56±22) h] significantly differ among STAP group, EA group and PCIA group (P<0.05). There was no difference in length of hospital stay between three groups. Conclusions General anesthesia combined with epidural analgesia or with subcostal transverse abdominis plane block is beneficial for the fast-recovery of gastric cancer patients subjected to radical operation. General anesthesia combined with intravenous analgesia has less analgesia, more side effects and longer recovery time.
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