Background　Anxiety is a common unfavorable reaction during perioperative period, and leads to harmful stress both physically and psychologically. Nowadays, no systemic effective therapy is available to prevent or reduce perioperative stress.　Objective　To systematically review non-pharmacologic intervention to relieve perioperative anxiety under the guidance of enhanced recovery after surgery.　Content　Perioperative anxiety has various adverse effects on patients, including immunosuppression, pain hypersensitivity, and slow recovery from surgery. Non-pharmacological psychological methods to treat perioperative anxiety include cognitive behavioral intervention, music entertainment, massage with communication, and perioperative education. This review introduces the concept of enhanced recovery after surgery to guide drug-free intervention of perioperative anxiety in the aspects of emotion, cognition and behaviors.　Trend　Compared with pharmacological therapy, psychological support has advantages in safety, comfort, no side-effect, and is an invaluable part in enhanced recovery after surgery.