国际麻醉学与复苏杂志   2017, Issue (7): 2-2
    
右美托咪定预防术后恶心呕吐的研究进展
白伟娜, 岳子勇1()
1.黑龙江省哈尔滨医科大学附属第二医院
Research progress of dexmedetomidine in prevention postoperative nausea and vomiting
 全文:
摘要：

背景　术后恶心呕吐（postoperative nausea and vomiting， PONV）发生率为20%~80%，右美托咪定（dexmedetomidine， Dex）是一种新型的高选择性α2肾上腺素受体激动剂，近来研究提示，Dex可能在预防和治疗PONV中发挥作用。　目的　了解Dex预防和治疗PONV的效果。　内容　综合相关文献，从Dex防治PONV的机制、优势、最佳剂量、应用时间、给药途径等方面探讨其防治PONV的效果。　趋向　Dex有望成为减少PONV发生的一种新的药物选择。
关键词： 右美托咪定；　预防；　术后恶心呕吐
Abstract:

Background The incidence of postoperative nausea and vomiting (PONV) ranges from 20% to 80%. Dexmedetomidine(Dex) is a potent and highly selective α2 adrenergic receptor agonist and recent studies suggest that Dex may be of vital role in prevention and treatment of PONV.　Objective　The effect of Dex in PONV prevention and therapy will be reviewed.　Content　Possible mechanisms, advantages and the best dose, application time and method of Dex in experimental studied were summarized in this review to explore the effect of Dex on the prevention and treatment of PONV.　Trend　Dex is expected to be a new drug option for reducing PONV.
Key words: Dexmedetomidine;　Prevention;　Postoperative nausea and vomiting