背景 术后认知功能障碍（postoperative cognitive dysfunction， POCD）是手术麻醉后出现的中枢神经系统并发症，常见于65岁以上的老年患者。 目的 分析总结右美托咪定（dexmedetomidine， Dex）改善老年患者POCD的可能机制及临床应用。 内容 简述POCD的流行病学资料及发病机制；详细分析Dex改善POCD的可能机制。 趋向 目前对于POCD的治疗还在探索之中，Dex能否改善POCD，需要进一步的研究和探索。
Background Postoperative cognitive dysfunction(POCD) is a complication of the central nervous system after surgical anesthesia, and commonly seen in elderly patients over 65 years old. Objective To summarize and analyze the possible mechanisms by which dexmedetomidine (Dex) improves POCD and the clinical uses of Dex. Content This article briefly described the epidemiological materials and pathogenesis of POCD, and analyzed the possible mechanism by which Dex improves POCD in detail. Trend At present, the treatment of POCD is still being explored. Whether Dex can improve POCD needs further research and exploration.
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