Background Massive blood loss in spinal surgery for adolescent scoliosis is a major concern for anesthesiologists. Researches have found factors associated with blood loss and built multivariate regression models. Objective This article is a summary of factors associated with blood loss in spinal surgery for adolescent scoliosis, and a discussion about effect of these factors. Content Significant factors affecting intraoperative blood loss of spinal surgery for adolescent scoliosis mainly include sex, weight, diagnostic type of scoliosis, Cobb angle, number of levels fused, osteotomy, duration of operation, fibrinogen, APTT, menstrual phase, antifibrinolytics. Trend More prospective researches with large sample size in multicenter are needed to identify validity,reliability and effectiveness of these factors and models.