Ｏｂｊｅｃｔｉｖｅ　To investigate the effect of dexmedetomidine combined with transversus abdominis plane block (TAPB) on the quality of recovery from anesthesia in minimally invasive abdominal surgery.　Methods　According to random number table, 114 cases of laparoscopic minimally invasive surgery were divided into 3 groups (n=38)： dexmedetomidine group (group D1), dexmedetomidine combined with TAPB group (group D2), TAPB group (group D3). MAP and HR in the 3 groups were recorded and compared at various time points： before induction, 10 min after the start of operation, 30 min after the start of operation, at the end of operation, at the time of extubation and 2 min after extubation. Respiratory rate（RR）, cough score, the maximum sedation-agitation scale at the time of the extubation and the residual sedation-agitation scale, numerical rating scale (NRS), nausea and vomiting score. Quality of recovery 40（QoR-40） in 24 h after operation were also recorded and compared.　Results　MAP and HR at various time points of 3 groups were of no statistically difference (P>0.05). RR after removing of the endotracheal tube, the time from the end of operation to removing of the endotracheal tube, cough score during the period of recovery time and the maximum sedation-agitation scale were not statistically significant different (P>0.05). NRS during the period of recovery in group D2 were statistically different with that of group D1 and group D3 (P<0.05), the differences of maximum sedation-agitation scale of 3 groups were not statistically significant (P>0.05). QoR-40 in group D1, group D2 and group D3 show statistically significant differences (P<0.05).　Conclusions　Dexmedetomidine combined with TAPB could effectively decrease cough and agitation score in recovery period from anesthesia and improve the QoR-40 in 24 h after operation.