Abstract: 【Abstract】Background Neuropathic pain is characterized as hyperalgesia,abnormal pain sensitivity and spontaneous pain,which is caused by neuronal damage or inflammation.The underlying mechanism is not well known yet .Objective To review the published studies about the role epigenetic modifications in NP.Content The Molecular basis of epigenetic,biological functions of epigenetic modification and the role of epigenetic in NP were discussed.Trend Advanced study in epigenetic modification in NP will be contributable target of the theraputic target.
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