In the past, many scholars have found that the heart, small intestine, etc. When these organs ischemia for some time, it will cause varying degrees of organ damage After the recovery of blood flow. The concept of ischemia reperfusion injury was concluded from the practice to the final conclusion. To explore the mechanism, it is conducive to the effective of prevention and treatment, so as to reduce the mortality of ischemic heart disease. Calcitonin gene related peptide is a kind of important sensory neuropeptide, which can decrease the myocardial ischemia reperfusion injury. To study the protective effect of CGRP on myocardial ischemia reperfusion injury, This maybe play a more effective role in myocardial protection.