Hemopexin (HPX) has the strongest affinity to heme in plasma, which can bind and transfer free hemes. Previous studies have proved that HPX possesses several functions such as antioxidant, anti-apoptosis, immune regulation and neuro-protection in a variety of disease processes. In recent years, the research on protection role of HPX in cerebrovascular disease continued making progresses. This article reviewed the main physiological function and the neuronal protection role of HPX in cerebrovascular disease, aimed to provide new ideas for the clinical use of HPX in cerebrovascular disease．