Background The breastfeeding mother may require anesthesia and surgery. The lack of reliable information on breastfeeding mothers and drug effects on their breastfed infants often leads to mothers being inappropriately discontinue breastfeeding after surgery. Objective To review the progress on affect of perianesthetic Breastfeeding to infant. Content The nursing infant’s drug exposure is affected by the drug concentration in maternal serum at the time of feeding, half life period of drugs, the amount of breast milk ingested by the infant, and the infant’s weight. Drugs are classified five levels based on their safety for nursing infants: Safest, Safer, Moderately safe, Possibly hazardous and Contraindicated. Mothers of premature or other otherwise compromised infants may require altered dosing to avoid drug toxicity in these infants with decreased clearance and Individually evaluated the effects of breastfeeding to infants. At last we list the latest safety grading of commonly used drugs. Trend In general, the benefits of breastfeeding outweigh the risk of exposure to most therapeutic agents via human milk.