一氧化氮(nitric oxide, NO)作为体内重要的气体信号分子,对缺血/再灌注(ischemia/reperfusion, I/R)心脏具有重要的保护作用。NO通过环磷酸鸟苷酸(cyclic guanosine monophosphate, cGMP)依赖的蛋白激酶(cGMP-dependent protein kinase, PKG)以及蛋白质巯基(-SH)亚硝基化(S-亚硝基化)在心脏I/R过程中发挥保护作用。文章综述体内NO的合成及其在心脏I/R过程中的作用、NO的心脏保护机制、NO在临床心脏保护中的应用。为NO的心脏保护作用的进一步研究提供参考。
As an essential gaseous signal molecule, nitric oxide (NO) has an important role in cardioprotection after ischemia/reperfusion (I/R). To provide insights for further study of NO in cardioprotection, this article reviewed the research progress on NO synthesis, its role in cardiac I/R injury, cardioprotective mechanisms, and its clinical application. The cardioprotective effects of NO in cardiac I/R may produce via the cyclic guanosine monophosphate(cGMP)/cGMP-dependent protein kinase(PKG) signaling pathway and protein S-nitrosylation. The commonly used cardioprotective measures and drugs are dependent on NO to various extents.
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