Background　Postoperative sore throat (POST) is a common complication following endotracheal intubation under general anesthesia. Although it is self-limiting, it greatly reduces postoperative comfortableness and satisfaction. Thus, in recent years, this issue has attracted much attention from anesthesiologists.　Objective　To summarize the pharmacological and non-pharmacological strategies for the prevention and treatment of POST in order to provide references for anesthesiologist to improve prognosis of patients undergoing endotracheal intubation.　Content　The currently available medications used for the intervention and treatment of POST include lidocaine, steroids, non-steroidal anti-inflammatory drugs, and others. There are some non-pharmacological methods being applied postoperatively, such as, capsule management, core application, and tracheal catheter softening. The efficacy of these methods to reduce the incidence of POST in patients underwent endotracheal intubation are individually summarized in this article.　Trend　Appropriate combination of pharmacological and non-pharmacological methods could minimize the distress of endotracheal intubation and prevent POST.