Recent studies have shown that angiotensin Ⅱ (AngⅡ) may act as a neurotransmitter or neuromodulator in the spinal transmission of nociceptive information. This review illustrated the action site of AngⅡ, the localization of AngⅡ receptors and the mechanism of angiotensin peptides involved in pain in the central nervous system, to review the relationship between renin-angiotensin system (RAS) and pain in the central nervous system and provide reference for the treatment of postoperative pain. RAS will become new targets for the treatment of postoperative pain, which needs to be further investigated.