老年人常伴发认知功能减退，成体海马神经发生是维持大脑正常认知功能的重要基础，衰老过程中海马神经发生水平明显下降。外周或中枢慢性炎症反应可抑制海马神经发生，是老年认知功能减退的重要机制之一。文章综述外周和中枢炎症反应对海马神经发生的调控及其在老年认知功能减退中的作用，为老年认知功能减退病理生理机制的进一步研究奠定基础，为老年认知功能减退的预防与治疗提供新思路。
The elderly patients often suffered from cognitive decline. Chronic inflammatory responses inhibit hippocampal neurogenesis, which is one of the important mechanisms of cognitive decline in the elderly patients. To provide insights for further study and new thoughts for prevention or treatment of cognitive decline in elderly patients, this article reviewed the research progresses on regulation of peripheral and central inflammation to hippocampal neurogenesis and their role in cognitive decline in elderly patients.
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