国际麻醉学与复苏杂志   2018, Issue (7): 0-0
    
不同剂量的右美托咪定复合罗哌卡因椎旁阻滞对小儿开胸手术苏醒期躁动的影响
杨婷, 邱永升1()
1.郑州市儿童医院
The effects of paravertebral block with different doses of dexmedetomidine combined with ropivacaine on the emergence agitation of Pediatric thoracotomy
 全文:
摘要:

目的 观察不同剂量的右美托咪定复合罗哌卡因椎旁阻滞对小儿开胸手术苏醒期躁动的影响。方法 择期开胸手术患儿共120例随机分为四组:右美托咪定组(D1、D2、D3组)和对照组(C组)。D1~D3组用药分别为右美托咪定(0.5、0.75、1.0ug/kg)+0.375%罗哌卡因,C组为单纯0.375%罗哌卡因。记录患儿麻醉时间、术后清醒时间(手术结束至自然睁眼)、拔管时间。观察术后即刻(T0)、10分钟(T1)、15分钟(T2)、拔管时(T3)的MAP、HR。记录患儿拔管时(T3)镇静-躁动评分及患儿拔管后5min(T4)、10min(T5)、苏醒时(T6)镇静评分及不良反应。结果 (1)与C组相比,D1、D2、D3组患儿的拔管时间及苏醒时间增加,但差异无统计学意义(P>0.05)(2)D1~D3组T0、T1、T2、T3各时间点MAP、HR明显低于C组;D2、D3组T0、T1、T2、T3各时间点MAP、HR明显低于D1组;D2、D3组T0、T1、T2、T3各时间点MAP、HR差异无统计学意义。(3)D1、D2、D3组T3时躁动评分明显低于C组,D1、D2、D3组Ramsay评分明显高于C组,差异有统计学意义(P<0.05)。D1、D2、D3组之间比较,D2、D3组躁动评分低于D1组,D2、D3组Ramsay评分明显高于D1组,差异有统计学意义(P<0.05)。D2、D3组差异无统计学意义。结论 右美托咪定复合罗哌卡因椎旁阻滞能有效预防小儿开胸手术苏醒期躁动。

关键词: 右美托咪定;罗哌卡因;小儿开胸手术;躁动
Abstract:

Objective To observe the effects of paravertebral block with different doses of dexmedetomidine combined with ropivacaine on emergence agitation of Pediatric thoracotomy.Methods A total of 120 children with thoracic surgery were randomly divided into four groups: dexmedetomidine groups (D1, D2, D3) and control group (group C).Groups D1~D3 were given with dexmedetomidine (0.5, 0.75, 1ug/kg)+0.375% ropivacaine, group C was given only 0.375% ropivacaine.The anesthesia duration , and postoperative recovery time (the end of operation to natural openning eyes), and the time of extubation were recorded. MAP and HR were observed at the time point of the end of operation(T0 ),10 minutes (T1), 15 minutes (T2), extubation (T3) postoperation .Agitation scores was recorded at the time of extubation.Ramsay scores and adverse complications were recorded at the time point of 5 minutes (T4), 10 minutes (T5), awaking time (T6) after extubation.Results (1) Compared with group C ,the extubation time and recovery time were extended in group D1, D2 and D3 ,but there was no statistically significant difference .(2) MAP and HR of groups D1~D3 were significantly lower than group C at the time point of T0, T1, T2, T3 .MAP and HR of groups D2~D3 were significantly lower than group D1 at the time point of T0, T1, T2, T3 .There were no significant difference of MAP and HR between group D2 and group D3.(3)The Agitation scores in groupsD1, D2 and D3were significantly lower than that in group C at the time point of T3, and the Ramsay scores in groups D1, D2 and D3 were significantly higher than that in group C(P<0.05).The Agitation scores in groupsD2 and D3 were significantly lower than that in group D1, and the Ramsay scores in groups D2 and D3 were significantly higher than that in group D1(P<0.05).There was no statistically significant difference between group D2 and D3 .

Key words: Dexmedetomidine;Ropivacaine;Pediatric thoracotomy;Emergence agitation