Objective To assess the analgesic effect, adverse events and fracture healing of ibuprofen comparing to other analgesics on the children with fracture. Methods We searched seven electronic databases including Medline, EMBASE, Cochrane Library, Web of Science, CBM, CNKI and Wanfang. Two independent reviewers identified the eligible studies, extracted the data and evaluated the risk of bias of the included studies. We chose the random or fixed effect model to synthesize the data based on the result of the test of heterogeneity. Results We totally included six studies with 1225 patients. The study design and conduction of the included studies were scientific, reasonable, rigor and standardized. Compared to the other analgesics, the analgesic effect of ibuprofen was inferior at half an hours after taking the medication (SMD = -0.25，95%CI：-0.48~-0.02，P=0.03), but better at one and two hours after taking the medication (SMD = 0.61，95%CI：0.03~1.19，P=0.04；SMD = 0.88，95%CI：0.57~1.18，P<0.00001, respectively), while there was no difference of the analgesic failure between ibuprofen and other analgesics (RR = 0.83，95%CI：0.64~1.08，P=0.16). For the adverse effects, the incidences of total adverse events, nausea, vomiting and drowse of the ibuprofen group were lower than the other analgesics group. With regards to fracture healing, there was no difference between the two groups (RR = 0.99，95%CI：0.18~5.55，P=0.99). Conclusions At one and two hours after taking the analgesic medication, the analgesic effect of ibuprofen were better than the other analgesics. Ibuprofen also resulted in the lower incidences of total adverse events, nausea, vomiting and drowse than the other analgesics. But there was no difference on fracture healing between ibuprofen and the other analgesics.