Ｏｂｊｅｃｔｉｖｅ　To explore the effect of dexmedetomidine(Dex) on pediatric emergence agitation after strabismus surgery under combinatorial anesthesia with sevoflurane and sufentanil.　Methods　One hundred and twenty children with strabismus were randomly divided into 2 groups (n=60): Dex group (group D: Dex+sevoflurane+sufentanil) and control group (group C: saline+sevoflurane+ sufentanil). Children in group D received intravenous infusion of 0.6 μg/kg Dex 15 min prior to induction of anesthesia, whereas children in group C received an equivalent dose of normal saline. Craner Pediatric Anesthesia Emergence Delirium(PAED) score for emergence agitation assessment, incidence of emergence agitation and postoperative adverse events were recorded.　Results　Compared with group C, patients in group D showed lower PAED score, less incidence of emergence agitation and postoperative adverse events.　Conclusions　Dex can effectively reduce the incidence of emergence agitation after pediatric anesthesia with sevoflurane and sufentanil for strabismus surgery.