Due to pharmacokinetic changes, morbidly obese (MO) patients often require a method to calculate propofol doses in anesthesia induction and maintenance, which is very different from normal weight patients. Based on the literature published in recent years at home and abroad, this paper analyzes the pharmacokinetics of propofol and appropriate dosage calculation methods in MO patients, so as to provide evidence for relevant research and rational use in the future.