Objective　To observe the application of staged goal-directed fluid therapy (GDFT) in anesthesia for renal transplantation.　Methods　A total of thirty patients scheduled for allogeneic renal transplantation were randomly divided into two groups, groups A and B (n=15). Group A was given staged goal-directed fluid therapy [stroke volume variation (SVV) ≤13 was set in accordance with the surgical progress before refusion in the new kidney and ≤10 after refusion, which is the basis of fluid management]. Meanwhile, group B was given goal-directed fluid therapy(where SVV≤13 was set). Then, the mean artery pressure (MAP), heart rate and stroke volume (SV) were recorded before the surgery after anesthesia, before refusion in the new kidney and 15 min after refusion. Furthermore, the content of blood lactic acid before and after surgery, the blood creatinine (Cr) content and urine volume before the surgery and 1, 2 d and 3 d after surgery were also recorded.　Results　There was no differences in MAP, heart rate and SV between the two groups before surgery (P>0.05). Group A presented remarkably increases in MAP and SV before refusion and 15 min after refusion, compared with group B (P<0.05). The content of blood lactic acid was marked increased in both groups A and B after surgery (P<0.05), while the increase of lactic acid in group A was significantly lower than that in group B (P<0.05). The Cr content in groups A and B was remarkably decreased 1, 2, 3 d after surgery, compared with those before surgery (P<0.05), where the Cr content in group A was markedly lower than that in group B 1, 2, 3 d after surgery (P<0.05). However, no difference was found in urine volume between both groups A and B (P>0.05).　Conclusions　Application of staged goal-directed fluid therapy in anesthesia for renal transplantation is favorable for recovery of renal functions after renal transplantation, if adequate blood perfusion can be ensured for the kidney.