【Abstract】 Objective To observe the effect of multimode anesthesia monitoring and management in the operation of elderly patients with gastrointestinal tumor with fragile brain function. Methods 109 cases of patients with fragile brain function who underwent elective total intravenous anesthesia for gastrointestinal tumor surgery were divided into observation group (58 cases) and control group (51 cases). The observation group received multimode anesthesia monitoring and management during the operation, while the control group received routine anesthesia monitoring and management during operation. Results The observation group using propofol and cisatracurium besylate were significantly less than the control group (P0.05); the postoperative ramsay sedation score of observation group at 1h、6h、24h、72h was significantly higher than the control group (P0.01), the postoperative VAS pain score at 10min、1h、6h、24h、48h was significantly lower than the control group (P0.01); the HR at T1-5 time and MAP at T2-5 time of observation group were significantly lower than the control group (P0.01); postoperative observation group and called the open end of the operation time, extubation time, PACU dwell time and hospitalization time were significantly shorter than the control group (P0.01); the patients in the observation group 72h in total POD incidence of the observation group was significantly lower than the control group (P0.05). Conclusion The application of multi mode anesthesia monitoring and management in the operation of elderly patients with gastrointestinal cancer with fragile brain function is satisfactory.