Ｏｂｊｅｃｔｉｖｅ　 To study the anesthesia and analgesic effect of modified thoracic nerve block(transversus thoracic muscle plane-pectoral nerves block) combined with general anesthesia in radical mastectomy.　Methods　A total of sixty-six patients who underwent radical mastectomy were randomly divided into three groups (22 cases in each group) by random number table: transversus thoracic muscle plane combined with pectoral nerves block group (group PG), thoracic paravertebral blockade group (group TG) and control group (group G). All patients in three groups were also anesthetized by general anesthesia. The blood pressure, heart rate and the consumption of opioids were recorded in the operation. The Visual Analogue Score (VAS), Ramsay sedation score and the recovery of bowel function were evaluated in the post-operation.　Results　Intraoperative blood pressure and heart rate of patients in group PG were more stable than these indexes of patients in group G and group TG. Compared with patients in group G, the consumption of sufentanil was low in group PG and group TG (P<0.05). The recovery time of bowel function in group PG and group TG was significantly shorter than group G. The rates of postoperative nausea and vomiting in patients of both group PG and group TG were less than the rates in patients of group G (P<0.05). Compared with group G, VAS scores in group PG and group TG decreased significantly from 30 minutes to 24 h after surgery (P<0.05). There were no differences in the consumption of sufentanil, the time of exhaust, the incidence of nausea and vomiting in patients of group PG and group TG (P>0.05), but the VAS score in group PG was lower, especially immediately after operation (P<0.05).　Conclusions　Modified thoracic nerve block combined with general anesthesia is safe and effective in radical mastectomy with low consumption of sufentanil， stable hemodynamic change and low incidence of postoperative complications.