Objective：To evaluate the efficacy of ultrasound-guided stellate ganglion block (U-SGB) combined with high intensity laser therapy (HILT) in the elderly with postherpetic neuralgia(PHN) on head and face. Methods：A total of 80 elderly patients with PHN on head and face were randomly assigned to the control group (group A, n=40) and the test group (group B, n=40). Both groups were treated with conventional drug therapy including nuerotrophic drugs and analgesics and received U-SGB; high intensity laser therapy (HILT) was set on the basis of drug therapy and U-SGB in group B. The curative effect was evaluated at 1month, 2months and 3months after the end of the treatments by numerical rating scale (NRS), pittsburgh sleep quality index (PSQI), Hamilton depression scale (HAMD), and Hamilton anxiety scale (HAMA). Results：NRS, PAQI, HAMD and HAMA in both groups decreased significantly at different time points after treatments compared with basal (P<0.05). Group B showed significantly lower NRS at 1 month and 2 months after treatments and lower PSQI at all time points compared to group A (P<0.05); Significantly lower HAMD and HAMA at 1month was also noticed in group A compared to group B (P<0.05). The overall efficacy was significantly higher in group B (P<0.05). Conclusion：U-SGB in combination with HILT is significantly more effective than the U-SGB alone in relieving pain, improving sleep quality and alleviating anxiety and depression severity in elderly patients with PHN on head and face.