Alzheimer's disease (AD) is a neurodegenerative condition caused by multiple factors. There is currently no effective treatment for AD, and it is still quite difficult to perform effective early intervention before symptoms appear. The entorhinal cortex (EC) is closely associated with memory and may present impairments at the early stage of AD. This paper is to review the structure and function of EC, the role of EC in the pathogenesis of memory impairment in AD patients, and early intervention of EC for AD treatment.