氯胺酮在麻醉方面的作用与机制已经被广泛研究和报道。近年研究发现，氯胺酮与炎症反应密切相关，可作为炎症反应和应激诱导免疫紊乱的一种调节剂，在炎症相关疾病的发生、发展中具有正负调节作用。文章主要针对氯胺酮在脓毒症及炎症性疾病中的抗炎、促炎作用及机制进行综述，为氯胺酮的临床转化应用提供新的靶点、方法和策略。
The role and mechanism of ketamine in anesthesia have been widely studied and reported. Recent studies have found that ketamine is closely associated with inflammation, which can be used as a regulator of inflammatory response and stress‑induced immune disorder and takes a positive or negative regulatory role in the pathogenesis of inflammation‑related diseases. The current review focuses on the anti‑inflammatory and pro‑inflammatory effects and mechanisms of ketamine in sepsis and inflammatory diseases, so as to provide new targets, methods and strategies for the use of ketamine in medical practice.
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