国际麻醉学与复苏杂志   2020, Issue (9): 7-7
    
趋化因子CX3CL1及其受体CX3CR1在阿尔茨海默病中的作用研究进展
沈阳, 姚俊岩1()
1.上海交通大学附属第一人民医院麻醉科
Research advances on the role of chemokine CX3CL1 and its receptor CX3CR1 in Alzheimer′s disease
 全文:
摘要：

阿尔茨海默病（Alzheimer's disease, AD）的发病原因及机制目前尚未明确。近年来，趋化因子CX3CL1及其受体CX3CR1在多种神经退行性病变中的作用获得了广泛关注。文章主要阐述趋化因子CX3CL1及其受体CX3CR1的结构与功能，CX3CL1及其受体CX3CR1与AD的关系，CX3CL1及其受体CX3CR1在AD发生和发展中的作用机制以及CX3CL1的受体外途径，为后续研究提供参考依据。
关键词： CX3CL1； CX3CR1； 阿尔茨海默病
Abstract:

The pathogenesis and mechanism of Alzheimer's (AD) disease has not been uncovered. In recent years, the role of CX3CL1 and its receptor CX3CR1 in neurodegenerative diseases has gained widely attentions. This review mainly describes the structure and function of CX3CL1 and its receptor CX3CR1, the relationship between CX3CL1/CX3CR1 signaling and AD, the role of CX3CL1/CX3CR1 signaling in AD progression, and the receptor‑independent pathway of CX3CL1, providing a reference for future studies.
Key words: CX3CL1; CX3CR1; Alzheimer's disease