Objective To evaluate the effects of adrenaline, norepinephrine and methoxamine on pulmonary artery tension in a rat model of hypoxic pulmonary hypertension. Methods Totally 48 male SD rats were randomly divided into two groups: the normoxic control group (Group C) and the hypoxic intervention group (Group H). After 4 weeks, the body weight, right ventricular systolic pressure, right common carotid artery pressure, and the secondary pulmonary artery and superior mesenteric artery ring of the two groups were measured for different concentrations of epinephrine (adrenaline, AD) and norepinephrine (norepinephrine,NE) , methoxylated (methoxamine,MOX) reactivity. Results After 4 weeks, the body weight and mean arterial pressure of group H were significantly lower than those of group C (P 0.05), and the right ventricular systolic pressure was significantly higher than that of group C (P 0.05). The pulmonary artery ring in group H is less responsive to AD, NE, and MOX than the mesentery artery, while the pulmonary artery ring in group C is more responsive to AD, NE, and MOX than the normoxic group, and is more reactive than the mesenteric artery ring ; The mesenteric artery ring in group H was not significantly changed compared with group C. AD and NE were similar in response to pulmonary artery ring and maximum contractile tension in both groups, while MOX was weaker than AD and NE. Conclusion In the hypoxic pulmonary hypertension model, the pulmonary artery has a dose-dependent contractile response to AD, NE, and MOX, and has stronger reactivity and maximum contractile efficacy than normal pulmonary arterial rings. Compared with AD and NE, MOX has a weaker contraction effect on the pulmonary artery.