Objective: To observe the effect of iliac fascia block combined with general anesthesia in postoperative depression undergoing total hip replacement. Methods: Eighty patients of selective total hip replacement were divided into group N and group G. Group N was treated with iliac fascia block combined with general anesthesia while group G was only treated with general anesthesia. The visual analogue scale scores at rest and on movement were recorded 2h after surgery (T1), 6h after surgery (T2), 12h after surgery (T3), 24h after surgery (T4), and 3d after surgery (T5). The amounts of sedative drugs and analgesics as well as remedial analgesics after surgery were recorded. The incidences of nausea and vomiting were also recorded. The hospital anxiety and depression scale was applied before surgery as well as 1d and 3d after surgery. Results: The VAS scores at rest and on movement in group G at T1, T2, T3 and T4 were lower than that in group N (P0.05). The usage of sedative drugs and analgesics as well as remedial analgesics were significantly lower in group N (P0.05). The incidences of nausea and vomiting in group N were also lower (P0.05). The scores of HADS in group N were lower than those in group G one day after surgery (P0.05). There was a significant positive correlation between HADS score after 1d of surgery and VAS score at T1, T2, T3 and T4 (P0.05). There was also a significant positive correlation between HADS score after 3d of surgery and VAS score at T1 (P0.05). Conclusion: Iliac fascia block combined with general anesthesia can be safely applied to patients undergoing total hip replacement, reduce the postoperative pain and the harmful emotion after surgery and promote the recovery of patients.