Objective The present work compares the effects of different concentrations of ropivacaine in thoracic paravertebral block on postoperative analgesia after video‑assisted thoracoscopic lung cancer resection. Methods Eighty patients who underwent elective radical resection of lung cancer were divided into four groups according to random number table method (n=20): thoracic paravertebral block was administered at T4 and T7 level with normal saline in group C, 0.25% ropivacaine in group R1, 0.3% ropivacaine in group R2, and 0.375% ropivacaine in group R3. The blood pressures and heart rates at 0 (T0), 5 min (T1), 10 min (T2), 15 min (T3), 20 min (T4), 30 min (T5), 60 min (T6) after skin incision were recorded, the Visual Analogue Scale (VAS) scores at resting and coughing at 3, 6, 12, 24, 36, 48, 72 h after surgery were recorded, the amounts of morphine consumption, the times of analgesic pump pressing，and the adverse events were recorded within 72 h postoperatively. Results The averaged heart rates in groups R1, R2 and R3 were lower than those in group C at T1‒T4 (P<0.05). When compared with group C, the systolic blood pressure (SBP) of group R1, group R2 and group R3 decreased at T1‒T2 (P<0.05). The SBP in groups R2 and R3 were still lower than those in group C at T3‒T5 (P<0.05). The SBP in groups R3 were lower than those SBP in group R1 at T1‒T4 (P<0.05). Compared with group C, diastolic blood pressure (DBP) in groups R1, R2 and R3 decreased significantly at T1‒T3 (P<0.05) while DBP in group R3 was still lower than those DBP in group C at T4 and T5 (P<0.05). The VAS scores at resting at 3, 6, 12 h and 24 h after operation in groups R1, R2 and R3 were significantly lower than those in group C (P<0.05). The VAS scores at coughing at 3 h and 6 h after operation were lower compared to group C (P<0.05). But the VAS scores at coughing at 12 h after operation in group R3 remained lower than those in group C (P<0.05). However, there was no significant difference among the three groups (P>0.05). The amounts of consumption of morphine, the times of analgesic pump pressing, the incidences of nausea, vomiting and dizziness in groups R1, R2 and R3 within 72 h after operation were lower than those in group C (P<0.05). But there was no significant difference among the three groups (P>0.05). Conclusions Compared with the 0.375% ropivacaine, 0.25% and 0.3% ropivacaine in two‑point ultrasound⁃guided thoracic paravertebral block can effectively control postoperative pain, reduce opioid consumption and postoperative adverse reactions, and facilitate more stable hemodynamics in patients undergoing thoracoscopic lung cancer resection.