Objective To evaluate the effects of different cuff pressures of the Supreme laryngeal mask airway on the blood flow of the internal jugular vein. Methods A total of thirty patients aged 18‒75 years who were scheduled for laparoscopic surgery under general anesthesia were enrolled. Doppler ultrasound was adopted to measure the cross‑sectional area, blood flow velocity and volume of the internal jugular vein at the median puncture site of the internal jugular vein before placement of the laryngeal mask airway, and when the cuff pressure was 60 cmH2O (1 cmH2O=0.098 kPa) and 120 cmH2O respectively. Results Compared with those before placement of the laryngeal mask airway, the cross‑sectional area significantly increased (P<0.05) and blood flow velocity and volume significantly decreased (P<0.05) when the cuff pressure was 60 cmH2O, the cross‑sectional area significantly increased (P<0.05) and blood flow velocity significantly decreased (P<0.05) while the blood flow volume changed with no statistical difference (P>0.05) when the cuff pressure was 120 cmH2O. There was no statistical difference as to the cross‑sectional area, blood flow velocity and volume when the cuff pressure was 60 cmH2O or 120 cmH2O (P>0.05). Conclusions Both the cuff pressures of 60 cmH2O and 120 cmH2O can result in the changes of congestion in the internal jugular vein at the same degree.