Objective To investigate the effect of allergic reaction caused by cystic hydatid disease on interleukin‑17 (IL‑17) and antibody expression. Methods One hundred and twenty female BALB/c mice were divided into three groups according to random values: blank control group (group A, n=45), cystic hydatid infection model group (group B, n=45), and cystic hydatid infection anaphylactic reaction group (group C, n=30). After the hydatid infection model was successfully established in groups B and C, group C was given crude capsular solution to stimulate anaphylactic reaction, and group B was injected with phosphate buffered saline (PBS). Serum samples were collected, and flow cytometry microbead array technology was used to detect the serum IL‑17 levels in mice. Serum immunoglobulin E (IgE) and immunoglobulin G (IgG) levels were detected using enzyme‑linked immunosorbent assay (ELISA) kits. Results Before sensitization, the levels of IL‑17, IgE and IgG antibodies in group B were significantly higher than those in group A (P<0.05). After sensitization, the levels of IL‑17, IgE and IgG antibodies in group B were significantly higher than those in group A, and the levels of IL‑17, IgE and IgG antibodies in group C were significantly higher than those in group B (P<0.05). Conclusions In hydatid anaphylactic reactions, IL‑17 is significantly increased as an inflammatory factor, IgE and IgG antibodies are also significantly increased, suggesting that IL‑17, IgE and IgG play an important role in the occurrence and development of alnaphylactic reactions caused by cystic hydatidosis.