目的 回顾性研究脑深部电刺激术中右美托咪定镇静对术后疗效的影响。 方法 回顾2016年6月至2019年5月在宣武医院行丘脑底核脑深部电刺激术的患者，按照是否应用右美托咪定镇静分为镇静组和对照组。主要结局指标为术后2周开机疗效。次要结局指标：围术期并发症，包括苏醒期谵妄、低氧血症、空气栓塞、颅内出血、癫痫。 结果 术后2周开机疗效右美托咪定镇静组改善率40.0±12.2%，对照组39.5±13.0%，P=0.797；镇静组苏醒期谵妄发生率6.1%，低于对照组15.1%，P=0.037。结论 右美托咪定镇静未降低脑深部电刺激术2周开机疗效。
Objective To study retrospectively the effect of dexmedetomidine sedation during deep brain stimulation on postoperative efficacy. Methods From 1st June 2016 to 31 May 2019, the patients who underwent deep brain stimulation of subthalamic nucleus in Xuanwu Hospital were reviewed. The patients were divided into sedation group and contrast group, it depends on whether dexmedetomidine was used for sedation. The main outcome was the efficacy of stimulator on 2 weeks after operation. The secondary outcome was perioperative complications, including emergence delirium, hypoxemia, air embolism, intracranial hemorrhage, epilepsy. Results Two weeks after operation, the improvement rate was 40.0 ± 12.2% in the dexmedetomidine sedation group, 39.5 ± 13.0% in the control group, P = 0.797. The incidence of emergence delirium was 6.1% in sedation group and 15.1% in control group (P = 0.037). Conclusion Dexmedetomidine sedation did not reduce the efficacy of deep brain stimulator (DBS) 2 weeks after surgery .
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