Because anesthetics are gradually metabolized completely during the peri‑extubation period, patients' tolerance to the endotracheal tube was decreased. Susceptible patients who have cardiovascular and cerebrovascular diseases are prone to cough and dramatic fluctuations in hemodynamics, which leads to complications. It is necessary for anesthesiologists to take measures to inhibit extubation reaction so that prevent complications during emergence of general anesthesia. This review described several methods for inhibiting extubation reaction: intravenous lidocaine, dexmedetomidine, targeted controlled infusion remifentanil, lidocaine local anesthesia, ropivacaine local anesthesia, compound lidocaine cream topical anesthesia and extubation under deeply anesthesia. Moreover, the advantages and disadvantages of these methods need to be clarified. This may provide a basis for further searching for better methods to suppress extubation reaction so as to reduce perioperative complications.