大型肝脏手术及肝移植手术时常伴随肝缺血再灌注损伤（hepatic ischemia reperfusion injury, HIRI），其与围手术期病死率、术后并发症等密切相关。既往研究均已证实预处理可通过调节体内肝细胞自噬水平来减轻HIRI。文章对近年来国内外通过调节肝细胞自噬水平减轻HIRI的预处理方式及其简要的生物学机制进行综述，为临床上采用合理的预处理方式以减轻HIRI及进一步研究提供参考。
Hepatic ischemia reperfusion injury (HIRI) is frequently associated with major liver surgery and liver transplantation, which is closely related to perioperative mortality and postoperative complications. Previous studies have confirmed that preconditioning can effectively relieve HIRI by regulating hepatocyte autophagy. This review summarized those preconditioning methods and biological mechanisms by which hepatocyte autophagy was regulated to alleviate HIRI, so as to provide reference for clinical use of reasonable preconditioning ways to alleviate HIRI and further research.
Cited
)
