【Abstract】 Objective To explore the clinical application of intravenous infusion of lidocaine in improving sleep quality and early functional rehabilitation of patients undergoing gynecological laparoscopy. Methods A total of 50 patients who underwent gynecological laparoscopy from September 2019 to July 2021 were divided into two groups based on the random number table method (n=25): an observation group and a control group. Based on the same anesthesia in both groups, lidocaine was infused intravenously in the observation group, patients in the control group were infused with normal saline of equal volume. Then, their systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, anesthesia duration, remifentanil dosage, sufentanil dosage 24 h after operation, and the time of first postoperative exhaustion were all recorded. Their Pittsburgh sleep quality index (PSQI) 1 d before surgery and 1, 3, 7 d and 30 d after surgery were recorded. The subjective sleep quality 1 d before surgery and 1, 2 d after surgery were measured. Their Ramsay sedation scores were recorded immediately, 30 min, 1 h, and 2 h after surgery. The Visual Analogue Scale (VAS) scores were calculated 30 min, 1 h, 2 h, 4 h, 8 h and 24 h after surgery. The MOS 36‑Item Short Form Health Survey (SF‑36) score [Physical Component Summary (PCS) and Mental Component Summary (MCS)] 1 and 2 months after surgery, and the incidence of perioperative adverse reactions were recorded. Results Compared with the control group, the observation group showed remarkable decreases in SBP, heart rate, remifentanil dosage, and sufentanil dosage 24 h after surgery (P<0.05), as well as an extended first postoperative exhaustion (P<0.05). The PSQI was lower in the observation group than in the control group 1, 3 d and 7 d after surgery (P<0.05); compared with those 1 d before surgery, the observation group showed decreases in PSQI 3, 7 d and 30 d after surgery and the control group presented decreases in PSQI 7 d and 30 d after surgery (P<0.05). At 1 d after surgery, the score of subjective sleep quality in the observation group was greater than that in the control group (P<0.05), and the score of subjective sleep quality in the control group was considerably lower 1 d after surgery than those 1 d before surgery (P<0.05). In the observation group, PCS and MCS scores were higher 1 month after surgery than those in the control group (P<0.001, P<0.05), and MCS scores in the observation group were higher than those in the control group 2 months after surgery (P<0.001). In comparison with the control group, the VAS scores of the two groups significantly decreased 30 min, 1 h, 2 h, 4 h, 8 h, and 24 h after operation (P<0.05). The VAS scores of the observation group dramatically decreased 30 min, 1 h, 2 h and 4 h after operation (P<0.05). At 30 min and 1 h after surgery, the Ramsay sedation score was lower in the observation group than in the control group (P<0.05). The observation group reported more perioperative skin rashes than the control group (P<0.05), with a lower risk of dizziness, nausea, vomiting, lethargy, and intestinal paralysis (P<0.05). There was no statistical difference as to other indexes (P>0.05). Conclusions Intravenous infusion of lidocaine can effectively enhance sleep quality for post‑operative patients and accelerate their functional rehabilitation.