急性肺损伤（acute lung injury, ALI）是由肺内或肺外致病因素导致肺上皮细胞和血管内皮细胞损伤，引起氧合功能障碍的一种急性炎症性疾病。ALI的发病机制被认为与炎症反应、氧化应激、细胞凋亡等病理生理过程相关，但其具体的调控通路尚不清楚。文章着重介绍了核因子‑红细胞2相关因子2（nuclear factor‑erythroid 2 related factor 2, Nrf2）/血红素氧化酶1（heme oxygenase 1, HO‑1）信号通路在ALI中的作用及其机制的研究进展，综述Nrf2/HO‑1信号通路在炎症反应、细胞凋亡、自噬、细胞焦亡及铁死亡中的作用，从而为临床治疗ALI提供新思路。
Acute lung injury (ALI) is an acute inflammatory disease caused by the damage of pulmonary epithelial cells and vascular endothelial cells induced by pathogenic factors inside or outside the lung, which causes oxygenation dysfunction. The pathogenesis of ALI is believed to be related to pathophysiological processes such as inflammation, oxidative stress, and apoptosis, but its specific regulatory pathway is still unclear. This article focuses on the role of nuclear factor‑erythroid 2 related factor 2 (Nrf2)/heme oxygenase 1 (HO‑1) signal pathway in ALI and the research progress of its mechanism. It reviews the role of the Nrf2/HO‑1 signal pathway in an inflammatory response, cell apoptosis, autophagy, cell scorch, and iron death to provide a new idea for the clinical treatment of ALI.
Cited
)
