干扰素基因刺激蛋白（stimulator of interferon genes, STING）作为先天免疫的组成部分，激活后可参与机体对异常双链DNA的防御。在中枢神经系统中，STING的异常激活与神经炎症间存在密切联系，进而影响慢性疼痛的发生与发展。文章对STING的病理生理作用，下游TANK结合蛋白1（TANK‑binding kinase 1, TBK1）/干扰素调节因子3（interferon regulatory factor 3, IRF3）、NF‑κB信号通路激活过程与STING及其下游因子通过影响神经元、小胶质细胞、星形胶质细胞参与慢性疼痛发生发展的可能机制进行综述，为以STING作为靶点缓解慢性疼痛的机制研究提供参考。
Stimulator of interferon genes (STING), as a component of innate immunity, can participate in the body's defense against abnormal dsDNA after activation. In the central nervous system, abnormal activation of STING is closely related to neuroinflammation, which in turn affects the occurrence and development of chronic pain. This article reviews the pathophysiological effects of STING, the activation process of its downstream TANK‑binding kinase 1 (TBK1)/interferon regulatory factor 3 (IRF3), nuclear factor‑κB (NF‑κB) signaling pathways, and the possible mechanisms by which STING and its downstream factors participate in the occurrence and development of chronic pain by influencing neurons, microglia, and astrocytes. These findings will provide reference for the research on the mechanism by which STING acts as a target to alleviate chronic pain.
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